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Ongoing research and investigational therapies, such as GIP/GLP-1/glucagon triple agonists, may inform future strategies for sustainable weight loss after discontinuation of weight loss pharmacotherapy
No Certainty Theres a lot of uncertainty with these estimates, which CBO admits
Most of them found that GLP-1 RAs, especially semaglutide can reduce the level of lipid in MASLD
Additionally, hepatokines play a role in IR and lipid metabolism in conditions like obesity, type 2 diabetes mellitus (T2DM), and other metabolic disorders, suggesting their potential as novel regulators of energy metabolism [8, 9]
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