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Recent observational studies have indicated that DPP4 inhibitors may exert a positive influence on baseline nigrostriatal dopamine degeneration and may improve long-term motor outcomes in PD patients with concurrent diabetes [97-101]
Regain begins within 4 to 6 weeks of last dose Appetite increases but remains below pre-treatment baseline Weight regain of 0.5 to 1 pound per week for 12 to 16 weeks, then plateau Patients report maintaining some dietary changes learned during treatment Net long-term outcome: retain 30 to 50% of weight lost on medication Typically occurs in patients who built structured meal patterns and exercise habits during treatment Pattern 3: Sustained maintenance without medication (approximately 15% of discontinuations)
16, Sonthalia, Sidharth, et al
Postbiotics are the metabolic byproducts and components of bacteria, including heat-inactivated bacterial cells, that deliver health benefits without requiring the organisms to be alive
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