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Diabetes Care (2020) 43(6):13525

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This might arise early in the pathogenesis of T2DM, as one of many risk factors contributing to the initial onset of hyperglycaemia in susceptible individuals, or later, as a consequence of already existing metabolic changes causing increased DPP-4 activity and further exacerbating the deterioration of glycaemic control

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Upon comparison, the potential side effects of semaglutide and tirzepatide are generally similar

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