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Combined enzyme deficiencies of -ketoacid dehydrogenase complexes pyruvate dehydrogenase complex, BCKDC and ketoglutarate dehydrogenase complexes have been observed due to genetic changes in human E3 [44] resulting in lactic acidemias and maple syrup urine disease [45-47]
expectedly, the use of ROS scavengers blocked the effect of iodide excess on Akt phosphorylation (as an element of the PI3K/Akt signaling pathway documented, among others, to downregulate NIS) [116]
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