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Additional information Competing interests The review is based on a round table discussion held in Frankfurt/Germany in June 2012

For most people, avoiding strenuous activity for a day keeps discomfort short and predictable

458 Adaptive platform trials enable flexible modifications, such as adjusting sample size, endpoints, or treatment arms, based on interim data, thereby optimizing resource allocation and accelerating trial progression

Lipidomic analysis of hepatocytes with different ApoE genotypes revealed that ApoE 4 may promote systemic metabolic imbalance by interfering with lipid distribution, glucose metabolism, and adipose tissue inflammation [84]