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Clinical trials show that patients on Wegovy (semaglutide 2.4 mg) achieve average weight loss of approximately 15% in non-diabetic populations (somewhat lower in those with type 2 diabetes), though individual results vary
The Wegovy label, covering the same active ingredient at weight-management dosages, reports fatigue a category including asthenia in 11% of 2,116 treated adults versus 5% of 1,261 on placebo in the pooled weight-reduction trials
GLP-1 receptor agonists have great therapeutic potential for treating diabetes and obesity
What to monitor: Everything listed above, plus liver function markers if accessible, heart rate (glucagon can modestly increase heart rate), and overall quality of life
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