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Besides, rapamycin and its analogs exhibit various side effects (including pneumonitis, immunosuppression, kidney toxicity and thrombocytopenia and impaired wound healing) complicating long-term therapeutic use (231) Developing next-generation rapamycin analogs may overcome these adverse effects while improving potency and pharmacokinetic profiles
E., Urthaler, F., Forrest, C., Shen, H., Durand, J., Wei, C
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