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Significance statement Acylation is a common strategy to enhance the pharmacokinetics of peptide-based drugs
GLP-1 medications may increase the risk of dehydration by reducing thirst and slowing digestion
Clinical trials demonstrated statistically significant increases in desire and arousal in both women and men
Activation of these receptors influences neural circuits related to satiety and may modulate neurotransmitter systems that affect motivation and affective tone
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