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Meanwhile, new formats are coming to market, including skin patches and nasal sprays
Pifithrin- alters p53 post-translational modifications pattern and differentially inhibits p53 target genes
beneficial effects observed even with pre-injury dosing (PMID: 19931318) Spinal cord injury Rescued tail function, reduced axonal necrosis, demyelination, and cyst formation after spinal cord compression in rats Peripheral nerve regeneration Promoted nerve regrowth after transection Dopamine system modulation Counteracted disturbances from receptor blockade, supersensitivity development, and nigrostriatal damage (PMID: 34380875) Hippocampal ischemia/reperfusion Protected against hippocampal damage in ischemia models The comprehensive review by Sikiric et al
Hsieh, M., Lee, C., Chueh, H., Chang, G., Huang, H., Lin, Y., & Pang, J
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