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Originally characterized at the University of Florida by the Stephen ORahilly and Robert Kraft groups, the compound has been studied in preclinical research for body composition, adipose tissue lipolysis, glucose homeostasis, skeletal muscle aging, and metabolic disease endpoints

Symptoms often develop gradually, making them easy to dismiss

This reduces blood sugar levels and decreases the amount of glucose available for conversion to fat

Preclinical studies showed preferential reduction of abdominal and visceral adipose tissue, suggesting favorable body composition changes even when total weight loss is moderate