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On the one hand, RA-FLSs secrete reactive substances, such as IL-6, MMP, and TNF-, which not only aggravate the process of bone erosion but also exacerbate the development of pannus (108)
In the case of ECs, the glycocalyx, as mentioned before, is a layer composed essentially of glycoproteins that reside on the surface of the cells and is the main element of their ventral microenvironment, in vivo [243]
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