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Adequate hydration (64-80 oz daily) supports the effectiveness of fiber and osmotic laxatives but won't resolve constipation by itself in most cases
J Pharmaceut Care Health Syst 2:e135 Menaa F, Menaa A, Menaa B (2014) Polyphenols nano-formulations for topical delivery and skin tissue engineering
In: StatPearls
Standard range: 200 to 500mcg once or twice daily The most commonly reported protocol across all sources is 250mcg twice daily
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