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For breeding, male VE-Cadherin-Cre ERT2 mice were crossed with female Igf1r f/f mice to generate VE-Cadherin-Cre ERT2 /Igf1r + / males, which were subsequently bred with Igf1r f/f females to establish the VE-Cadherin-Cre ERT2 /IGF1R homozygous floxed founder colony, following our previously described protocol [17, 45]
These models probe whether the triagonists metabolic effects extend to tissue-protective signaling in non-classical metabolic organs
Final Thoughts The "better" product depends entirely on the research question
In a foundational 2009 study, Li and colleagues found that GLP-1R stimulation preserved both cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism [5]
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