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Due to their high iron content, limited antioxidant capacity, strong reliance on oxidative metabolism, abundant lipid composition, and highly permeable glutamate receptors, oligodendrocytes exhibit unique vulnerability to ischemic injury in the CNS and often undergo irreversible damage ( + overload and mitochondrial dysfunction (62)

This shift is particularly relevant for procurement functions, which must balance cost efficiency with supply reliability in the face of increasing demand and constrained manufacturing capacity

More studies are needed to assess GLP-1s as a potential therapy for alcohol use disorder

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