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The issue of obesity and insulin resistance prompted the design of a number of studies investigating the effects of antidiabetic drugs in PCOS, as reported in recent and very exhaustive reviews on the available clinical trials on glucagon-like peptide 1 receptor agonists (GLP-1RA) in PCOS [21, 23, 24]
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Current research investigating potential advantages beyond glycaemic regulation and weight reduction, including impacts on non-alcoholic fatty liver disease, cardiovascular outcomes, and renal protection, may broaden the therapeutic uses of these medicines
US 5,863,940 describes the use of L-carnitine in combination with acetyl L-carnitine for the treatment of idiopathic oligoasthenospermia
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