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Chronic stress, environmental toxins, diets low in nutrients but high in inflammatory triggers, sleep deprivation, smoking, sugar, excess alcohol, and other stressors slowly deplete glutathione levels
References Abdalla MMI (2024) Insulin resistance as the molecular link between diabetes and Alzheimers disease
Importantly, primary human ILC2s exhibited conserved NRF2 activation, glutathione accumulation, and reduced type 2 cytokine production in response to melatonin, underscoring clinical relevance