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In mice, intravenous injection of fluorescently labeled pHLIP-Ku80 () targeted tumors and reduced Ku80 expression
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For instance, upon stimulation of myeloid cells, NADPH is significantly depleted due to consumption by inflammatory and anti-inflammatory pathways [25]
236 Furthermore, glucose starvation leads to a suppressed lactate/pyruvate cycle, which inhibits neovascularization, hypoxia-induced vascular epidermal growth factor activation, and angiogenesis, and causes ultimate necrosis in tumor cells, especially for colon adenocarcinoma xenografts
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