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16 Furthermore, as these models rely on immunocompromised hosts, they cannot replicate immune-related resistance mechanisms

It means the agency no longer has an active nomination designating dihexa as posing "significant safety concerns." That happened because the original nominator voluntarily withdrew their petition

Secondly, it may activate short-chain fatty acid receptors (SCFA receptors) and inhibit histone deacetylase (HDAC) activity, thereby lifting transcriptional repression on key iron absorption genes (such as Dcytb and Ferroportin) and consequently upregulating intestinal iron uptake

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