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Methylcobalamin and adenosylcobalamin are native forms of B12, while hydroxycobalamin or cyanocobalamin are not

The respiratory chains components experience chronic protein glycation as the illness worsens, which, when combined with the damaged DNA of mitochondria, can cause a series of events that are independent of hyperglycemia and result in a synergy between oxidative stress and AGEs [43]

Additionally, various molecular techniques, including Western blotting, reverse transcription, quantitative PCR, immunofluorescence, and immunohistochemistry, were utilized to examine the expression levels of angiogenesis-related factors and the Notch/NF-B pathways-related factors

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