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Emerging role of glutamate in the pathophysiology of major depressive disorder
Here's what that looks like: The Retatrutide Escalation Protocol (Phase 2 Trial Structure) Weeks 1-4: 2 mg subcutaneous injection, once weekly Weeks 5-8: 4 mg once weekly Weeks 9-12: 8 mg once weekly Weeks 13-16: 12 mg once weekly (highest dose arm) Week 17+: Maintenance at the highest tolerated dose In the Phase 2 trial published in The New England Journal of Medicine , participants in the highest dose group (12 mg) lost a mean of 24.2% of body weight at 48 weeks
As you titrate up through higher tirzepatide doses, you may need vials with higher tirzepatide concentrations to keep the injection volume manageable
you just have one vial, a set of needles, and a schedule to follow
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