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Consistent with this, the depletion of butyrate-producing bacteria and the concomitant reduction in intestinal butyrate levels reported in IBD patients compared with healthy individuals have highlighted the immunomodulatory role of this microbial metabolite (91, 100102)
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Considering the reduced biosynthetic capacity of erythrocytes, they accumulate oxidative changes along their life span and, therefore, the OS-induced changes in RBCs could be used as useful biomarkers in several pathological and physiological conditions
Among these alleles, 4 were obtained from lines collected before the use of DDT and so it is unlikely that the G171K change occurred in response to DDT selection
