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However, some patients may experience persistent fatigue, which warrants further clinical evaluation to exclude other contributing factors such as nutritional deficiencies (particularly iron, vitamin B12, or vitamin D), thyroid dysfunction, or inadequate protein intake
K., Wang, Y
Under high uracil misincorporation as occurs in severe folate deficiency or marked MTHFR impairment BER creates double-strand breaks when two abasic sites on opposite strands are cleaved in close proximity before repair is completed
Most clinicians recommend starting the new medication at its lowest dose and escalating even if you were on a high dose of the previous medication, because receptor sensitivity and side effect profiles differ
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