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( A C ) Plasma blood glucose (mmol/L), insulin levels (pmol/L), and GLP-1 levels (pmol/L) after male C57BL/6JRj mice received vehicle (black), 4 mg/kg SSTR2a (red), or SSTR5a (blue) by s.c
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The bioactivity of scExe4 was evaluated through measuring GSIS using pancreatic iGL cells, which release Gaussia luciferase-fused insulin in response to high glucose levels 21
Side Effects and Tolerability Profiles Both tirzepatide and semaglutide commonly cause nausea, vomiting, diarrhea, and constipation, particularly during dose escalation
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