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First: PI3K/Akt/mTOR, which drives protein synthesis, glucose uptake (via GLUT4 translocation), and anti-apoptotic signaling (particularly relevant in muscle and neuronal tissue)

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In this relation, a BMI of 30 kg/m 2 or higher is classified as obese [4], whose causes lie in excessive calorie intake or reduced energy expenditure, and modern lifestyles promote both a lack of exercise and an unhealthy diet

Nat Rev Mol Cell Biol 13(4):251262 He YK, Cen XT, Liu SS, Lu HD, He CN (2019) Protective effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1-induced rabbit osteoarthritis chondrocytes