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Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein

Pathological stimuli-including inflammatory cytokines and oxidative stress-trigger IKK-mediated IB degradation, enabling NF-B nuclear translocation and transcription of pro-inflammatory cytokines and atrophy-related genes (Scalabrin et al., 2020)

Whilst no patient exhibited an objective response, eight had stable disease, with one patient having stable disease for 18 weeks