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(Frontiers in Pharmacology, 2022) reports a half-life under 30 minutes after IM or IV administration in rodent and dog models, which is why split-dose schedules appear in the literature

If you dont have a vitamin B12 deficiency to begin with or you dont first address the underlying causes of a deficiency, high doses of vitamin B12 will not work to improve your quality of life

Note your energy levels to better track improvements after treatment

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