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NHS prescribing guidelines follow NICE recommendations (NG28), which specify that GLP-1 receptor agonists should be considered for adults with type 2 diabetes who have inadequate glycaemic control despite optimal treatment with other agents, and who meet specific criteria including BMI thresholds or where weight loss would benefit obesity-related comorbidities
Baxdrostat works by blocking aldosterone, a hormone that drives sodium and water retention, leading to vessel stiffness and long-term cardiovascular damage
The Timeline to Watch: 2026 (The Novo Milestone): Novo Nordisk is pushing CagriSema (GLP-1 + Amylin) into the filing stage
Standard semaglutide titration schedule Month 1: 0.25mg once weekly (tolerance assessment) Month 2: 0.5mg once weekly Month 3: 1.0mg once weekly Month 4: 1.7mg once weekly (if needed) Maintenance: 2.4mg once weekly (maximum dose for weight management) This schedule exists to minimize gastrointestinal side effects
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