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Among the possible mechanisms underlying DDIs, those related to delayed gastric emptying have been most extensively studied
These preclinical data suggest unimolecular poly-pharmacology as an effective means to target multiple mechanisms contributing to obesity, and further implicate glucagon receptor activation as the differentiating factor between incretin receptor mono- or dual-agonists and triagonists
Available at: Jastreboff AM, Aronne LJ, Ahmad NN, et al
However, glucose is the most potent secretagogue for insulin secretion as it induces robust insulin secretion within a few minutes of the onset of the stimulus and the stimulatory effect lasts as long as the plasma glucose is elevated
