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The glutathione can then be degraded by the cytoplasmic ChaC family of -glutamylamine cyclotransferases [ChaC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1) and ChaC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2)] generating 5-oxoproline and the dipeptide Cys-Gly
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The HF diet significantly reduced the fishs exploratory drive, as evidenced by the HF group spending a longer period in the start arm compared to the control group
This imbalance in calcium and metabolic regulation likely requires a multi-targeted therapeutic approach that addresses metabolic health, mitochondrial dysfunction, and inflammation which be better suited to fully rescue the BD phenotype
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