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Semaglutide and the other GLP-1 agonists have the added benefit of central effects on the hunger centres in the hypothalamus as well as delaying gastric emptying to increase fullness and suppress appetite, a valuable tool for both the treatment of diabetes and weight loss management, but a potential risk for the use of sedation/anaesthesia
This list reflects publicly available information as of June 2026
Patients should report serious side effects to their provider and to FDA MedWatch (1-800-FDA-1088 or www.fda.gov/medwatch)
In contrast, GLP-1RA lower SBP by an average of ~2 mmHg, with minimal or no consistent effect on DBP
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