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The antihyperglycemic agents, troglitazone (Rezulin) and rosiglitazone (Avandia) block pyruvate entrance into the TCA cycle(25,33] lowering KG(glutamate,7,25] and accelerating GDH flux via this pull mechanism (Figure 2)
By analyzing the proteins in the lateral septum of alcohol-consuming rats, the researchers found changes in specific proteins called histones
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