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These processes, in turn, decrease insulin-stimulated IRS-1/IRS-2 tyrosine phosphorylation, PI3K activation and downstream insulin signaling that then induces IR in muscles and livers

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Slower digestive pace can affect: Fullness and appetite : feeling satisfied faster Nausea : particularly when starting or increasing doses Constipation : from slower intestinal transit Diarrhoea : paradoxically, some people experience the opposite Bloating and abdominal discomfort : symptoms many IBS sufferers already know too well