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GLP-1 receptors in blood vessels may mediate direct protective effects
While higher doses of semaglutide generally provide greater appetite suppression, even the maximum dose (2.4mg for Wegovy) won't completely eliminate hunger
Moreover, the observation that adding GLP-1MK-801 treatment on top of semaglutide leads to an additional weight loss of 7% in mice that have reached a weight loss plateau with semaglutide provides additional support for integrating NMDA receptor antagonism in next-generation weight loss therapeutics
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