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This review applies a contemporary lens (20202025) reflecting methodological and clinical inflection pointswidespread continuous glucose monitoring (CGM), standardized assays for TRL, multi-omics workflows, and the clinical introduction of glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide (GLP-1/GIP) co-agonistswhile selectively incorporating pre-2020 foundational contributions limited to seminal meta-analyses, consensus statements, pivotal randomized trials, or first-in-field mechanistic studies
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