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Additionally, the proportion of exposure variance explained by instrumental variables was evaluated using R 2 , computed as R 2 = 2 EAF (1 EAF) 2 , where EAF denotes the effect allele frequency of the exposure

Two hydrogen bonds (D15 P -Y202 2.75b and R17 P -Y202 2.75b ) were only seen in GCGR

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