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Steroidogenesis can also be impaired, including decreased testosterone and progesterone production and increased LH and FSH production (102)
These species contribute to oxidative and nitrosative stress by promoting protein nitration and nitrosation reactions, thereby affecting enzyme activity and cellular signalling pathways
TNF-alpha: Inflammation, Chronic Diseases, and Genetic SusceptibilityTNF-alpha is a key inflammatory cytokine linked to autoimmune, cardiovascular, mood, and neurodegenerative diseases
The nitric oxide generated through this pathway promotes vasodilation, inhibits platelet aggregation, and enhances endothelial cell survival while supporting the formation of patent, functional vessels
