The risk of virilization (development of masculine characteristics) requires careful compound selection and dosing, but does not preclude beneficial use of these agents

Apovian has participated on advisory boards for AbbVie Inc., Altimmune, Inc., Arrowhead Pharmaceuticals, Inc., BioAge, Biolinq Incorporated, Caribou Biosciences, Inc., CinFina Pharma, Inc., Covidien LP, Cowen and Company, LLC, Currax Pharmaceuticals, LLC, EPG Communication Holdings Ltd., Form Health, Inc., Fractyl Health, Inc., Keros Therapeutics, Inc., Lilly USA, LLC, L-Nutra, Inc., Mediflix Inc., NeuroBo Pharmaceuticals, Inc., Neurocrine Biosciences, Inc., NodThera Limited, Novo Nordisk, Nutrisystem, OptumRx, Inc., Pain Script Corporation, Palatin Technologies, Inc., Pursuit By You, Redesign Health Inc., ReShape Lifesciences Inc., Riverview School, Roman Health Ventures Inc., Scholar Rock, Inc., Terns, Inc., Verily Life Sciences LLC, Veru Inc., Vida Health, Inc., Wave Life Sciences, WondrHealth, Xeno Biosciences and Zyversa Therapeutics, Inc

ACS Chem Neurosci 13(8):12631272 Van der Perren A, Cabezudo D, Gelders G, Peralta Ramos JM, Van den Haute C, Baekelandt V, Lobbestael E (2021) LRRK2 ablation attenuates lpha-synucleininduced neuroinflammation without affecting neurodegeneration or neuropathology in vivo
The rat receptor was cloned by expression cloning of an islet cDNA library followed by identification of human clones (25, 26, 41, 111)