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Current Drug Metabolism , 16
It is widely acknowledged that gastrointestinal factors, such as glucagon like peptide (GLP)-1 and gastric inhibitory polypeptide (GIP), interact directly with -cells to induce proliferation, and enhance resistance to apoptosis, thereby increasing/maintaining -cell mass (136, 137)
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A collagen research program may distinguish among: Collagen gene expression Procollagen-associated measurements Secreted collagen Matrix incorporation Fiber organization Cross-linking Proteolytic degradation Mechanical properties An increase in one collagen-associated marker does not establish functional tissue restoration or an anti-aging effect
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