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Novel Grb14-mediated cross-talk between insulin and p62/Nrf2 pathways regulates liver lipogenesis and selective insulin resistance
Irbesartan, an angiotensin receptor blocker, inhibits the activation of the Hippo/YAP1/TAZ signaling pathway, decreasing c-Jun expression, which upregulates iron metabolism genes and suppresses ferroptosis
However, its clinical application must be approached with a critical and nuanced understanding of the current evidence gap
Blood 98:696a, 2001
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