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A 2025 systematic review of BPC-157 in orthopedic sports medicine acknowledged the compelling preclinical data while noting the absence of human clinical trials as a critical limitation

These changes lead to the accumulation of damaged proteins in myocytes, thereby reducing their ability to adapt to physiological stress and increasing the risk of heart disease in old age

Hsieh MJ, Lee CH, Chueh HY, et al

While direct weight loss trials on sermorelin itself are limited, this controlled evidence with its GHRH analog demonstrates the biological pathway by which sermorelin may support fat reduction when GH signaling is successfully increased