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In the Phase 2 trial published in the New England Journal of Medicine in 2023, investigators assigned participants to placebo or to weekly amounts of 1 mg, 4 mg, 8 mg, or 12 mg over 48 weeks investigational quantities given under supervision
While tirzepatide generally produces superior weight loss results compared to semaglutide, its dual mechanism as both a GLP-1 and GIP receptor agonist can amplify gastrointestinal side effects for some individuals
Thinking About Taking a GLP-1 Drug
2 Osher, E
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