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Foundayo ( orforglipron ): a once-daily pill thats available in 0.8 mg, 2.5 mg, 5.5 mg, 9 mg, 14.5 mg, and 17.2 mg tablets
The scaffold is a 23-membered macrocycle closed by a lactam bridge between the aspartate side-chain carboxyl at position 5 and the lysine side-chain amine at position 10, with norleucine at position 4 in place of the oxidation-prone methionine of the native hormone and D-phenylalanine at position 7 inside the conserved His-Phe-Arg-Trp message core
However, heterogeneity was observed when estimating the effects on HDL-C, which may account for the nominally significant result of GLP-1R/GIPR on HDL-C
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