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By reducing liver fat, slowing fibrosis, and calming inflammation, GLP-1 therapies intervene at multiple points where metabolic stress accelerates hepatic aging
The removal of semaglutide from the FDAs drug shortage list represents a significant shift in the regulatory landscape for compounded GLP-1 medications and will impact the availability of compounded versions of these drugs
References: Anderson T, Grady D
In rodent models, peripheral administration of exendin-4 (EX4), a GLP-1RA has been shown to reduce motivation for sucrose, as evidenced by decreased responding in progressive ratio operant-conditioning tasks (Richard et al., 2015)
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