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Total weight loss at 48-68 weeks on the combination is difficult to predict without clinical trial data, but based on individual compound data (retatrutide at 24-28.7% and the additive benefit seen with CagriSema), a reasonable estimate for the combination is 25-35% total body weight reduction in high responders
The animal research itself shows remarkable consistency
A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity
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