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It is important to consult a provider about all supplements and medications to avoid potential interactions
For example, with folate (vitamin B9), plasma or serum concentrations reflect short-term dietary changes and may be affected by recent meals, which isn't ideal for detecting deficiency
Sirtuins, poly(ADP-ribose) polymerases and the CD38/CD157 ectoenzymes cleave the glycosidic bond between the nicotinamide and the ADP-ribosyl moiety, releasing nicotinamide stoichiometrically, so NAD+ is destroyed rather than recycled and must be resynthesised through the NAMPT-limited salvage pathway (Cant, Menzies and Auwerx, Cell Metabolism, 2015)
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