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Furthermore, there was an increase in the microphage activation marker Iba-1 in the spinal cord, suggesting that phagocytosis occurred in response to myelin debris production [82]
FDA's evaluation concluded that the criteria weighed against placement on the list, citing inadequate physicochemical characterization, immunogenicity concerns from impurities and aggregates, lack of clinical effectiveness data for any approved use, and absence of published human exposure data for the proposed subcutaneous and topical routes
Warnings and precautions: Keep refrigerated (2-8C) In case of long-term treatment, regular follow-up with the doctor is recommended
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