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Neurology 64 (9), 156372
The OPLS-DA model was used to analyze further the differences in ACs components between the ALF and NLF groups
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The offspring from dams fed with mixed choline sources with lower free choline (12.5-25%) but high glycerophosphocholine (25-75%), exhibited a decrease in macrophage and dendritic cell frequencies in the spleen and produced less IL-1, IL-6 and IFN- in response to mitogenic immune challenge with either concanavalin A or LPS, compared to those from dams with higher free choline (100%) intake ( de novo PC biosynthesis ( de novo PC synthesis, accelerated PC turnover, and proinflammatory adipose tissue macrophage activation ( In dendritic cells, ACh modulates immune function by upregulating HLA-DR and CD86 expression and stimulating TNF- and IL-8 production ( Enterobacter ludwiggi , an abundant commensal bacterial species in mice, enhances dendritic cell immune tolerance and promotes Treg differentiation via choline metabolism ( E
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