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And because excess weight drives so much of what harms us, and because GLP-1 receptors turn out to sit all over the body, these drugs have shown benefits well beyond weight including for heart disease
For example, a small retrospective study of 30 obese HS patients treated with weekly semaglutide (~0.8 mg for ~8.2 months) resulted in a 5% weight loss, a reduction in flare frequency (every 8.5 weeks to every 12 weeks), modest reductions in inflammatory markers like HbA1c and CRP, and improvement in DLQI (13 to 9)
Nasal sprays still carry the unregulated product problem
For other medications, the primary consideration is ensuring that antacids themselves do not interfere with the absorption of any other oral medications you may be taking concurrently
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