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The REDEFINE 3 cardiovascular outcomes trial which will take several years to complete is not a prerequisite for initial market authorisation for obesity treatment, but its results will likely be important for subsequent label expansion and for establishing the cardiovascular benefit profile that has proven so valuable for tirzepatide and semaglutide
As compared to healthy controls, subjects with current or remitted MDD presented similarly lower mean C2 levels (Cohens d = 0.2, p 1e-4)
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Weight loss is a personalized journey, and using Semaglutide GLP-1 is no different in this respect
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