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mimicked CR in cells by reducing glucose concentrations in cell growth medium, and experimentally demonstrated that glucose restriction can directly activate SIRT1, which can bind to the p16INK4a gene promoter, resulting in chromatin remodeling of the gene promoter and decreased expression of this gene significantly prolonging cell life
doi:10.1016/j.xkme.2023.100730
This process enables horses to access stored fat more efficiently, which supports endurance during exercise and helps prevent fatigue
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